This invention relates to substituted 4-pyridones of formula 1and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other auto-immune and allergic disorders, allograft rejection, and oncological diseases.本發明係關於式1之經取代之4-吡啶酮及其作為嗜中性白血球彈性蛋白酶活性抑制劑之用途，含有其之醫藥組合物，以及使用其作為治療及/或預防以下之藥劑之方法：肺、胃腸及生殖泌尿疾病、皮膚及眼睛之發炎疾病以及其他自體免疫及過敏性病症、同種異體移植物排斥及腫瘤疾病。
