KIM, Sung-Wuk,MIN, Chang-Hee,KOO, Ja-Seong,SUN, Sang-Ouk,KIM, Yong-Eun
申请号：
KRKR2012/006096
公开号：
WO2013/019058A3
申请日:
2012.07.31
申请国别(地区):
WO
年份:
2013
代理人:
摘要：
The present invention relates to a pharmaceutical composition for inhibiting cancer recurrence or metastasis and a method for inhibiting cancer recurrence or metastasis using the same. The present invention identified the activity of 2-deoxy-D-glucose (2-DG, below) for the inhibition of mammosphere formation and EMT, indicating its inhibitory effect against proliferation of cancer stem cell and cancer metastasis, which has not been known hitherto. The present invention also identified that the combined use of a biguanide based antidiabetic agent or its pharmaceutically acceptable salt and 2-DG can inhibit cancer metastasis and steeply decrease cancer recurrence in comparison to the single use of said active ingredients, resulting in a superior effect in the inhibition of cancer metastasis and recurrence when the same dosage is applied. Therefore, the pharmaceutical composition of the present invention can be used to show substantially more excellent effect with less amount of each active ingredient, reducing the side effects due to the use of excess drug and due to their pharmacological action, and providing more efficacious treatment. Moreover, when it is used along with an anticancer agent to which resistance is shown, it is expected that more synergistic effect can be exhibited. Therefore, the pharmaceutical composition and method for inhibiting cancer recurrence or metastasis according to the present invention can be used very advantageously for the treatment and prevention of metastasis or recurrence of various cancer diseases.La présente invention concerne une composition pharmaceutique destinée à inhiber la récidive du cancer ou les métastases, et un procédé dinhibition de la récidive du cancer ou des métastases utilisant ladite composition. Dans le cadre de linvention, lactivité du 2-désoxy-D-glucose (2-DG) dans linhibition de la formation de mammosphère et de TEM a été identifiée, montrant ainsi son effet inhibiteur ‑ non connu jusquà présent ‑ contre la pr
