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Implantes para el tratamiento de estados asociados con dopamina
专利权人:
NUPATHE INC.
发明人:
SEBREE, TERRI B.,SIEGEL, STEVEN J.
申请号:
ES07755118
公开号:
ES2402376T3
申请日:
2007.04.06
申请国别(地区):
ES
年份:
2013
代理人:
摘要:
biodegradable implant for use in biodegradable tratamienImplante for use in treating a subject for a condition associated with dopamito of a subject for a condition associated with dopamine, said implant comprising a biocomna polymer, said implant comprising a biocompatible polymer and / or biodegradable and effective amount depatible and / or biodegradable and an effective amount of uncompuesto dopamine modulating being December uncompuesto dopamine modulating, said compound being dopamine modulating one agonistaho compound dopamine modulating one agonistade dopamine selected from the group is thus dopamine selected from the group consisting of apomorphine, lisuride, pergolide, bromocriptine, pr apomorphine, lisuride, pergolide, bromocriptine, pramipexole, rotigotine, docarpamine, terguride, cabeamipexol, rotigotine, docarpamine, terguride, cabergoline, levodopa, spheramine, romergolina, carmoxrgolina, levodopa, spheramine, romergolina, carmoxirol, zelandopam, sumanirole, sibenadet a compuestirol, zelandopam, sumanirole, sibenadet, a compound 4-alkylamino-2 (3H) -indolone a compound deo 4-alkylamino-2 (3H) -indolone a defórmula compound ( 1), ropinirole and combinations mismfórmula (1), ropinirole and combinations thereof, wherein said compound of formula (I): in qos, wherein said compound of formula (I): wherein: R is amino, alkylamino, dialkylamino, alquenue: R is amino, alkylamino, dialkylamino, alkenylamino, dialkenylamino, N-alkyl-N-alquenilaminoilamino, dialkenylamino, N-alkyl-N-alkenylamino, benzylamino, dibenzylamino, arylalkylamino or day, benzylamino, dibenzylamino, arylalkylamino or diarilalquilamino R1, R2 and R3 are each independirilalquilamino R1, R2 and R3 are each independently hydrogen or alkyl n is 1, 2 or 3, and ently hydrogen or alkyl n is 1, 2 or 3, and pharmaceutically acceptable salts thereof, pharmaceutically acceptable compsales thereof, said implant comprising a said hidrófobrendiendo coating implant a hydrophobic coating, said condition a
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