METHODS FOR PREPARATION OF CYTOTOXIC CONJUGATES OF MAYTANSINOIDS AND CELL BINDING AGENTS

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专利权人:

IMMUNOGEN INC.

发明人:

CHARI, RAVI V.J.,WIDDISON, WAYNE C.

申请号：

HK11107839.7

公开号：

HK1149765B

申请日:

2004.05.10

申请国别(地区):

HK

年份:

2016

代理人:

摘要：

The present invention discloses a one-step process for the production of cytotoxic conjugates of maytansinoids and cell binding agents. Maytansinoids having a disulfide linker that bears a reactive moiety are linked to cell binding agents, such as antibodies, without prior modification of the cell binding agent. These conjugates are useful as therapeutic agents which are delivered specifically to target cells and are cytotoxic.

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