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“SELENIUM CONTAINING MODIFYING AGENTS AND CONJUGATES”
专利权人:
发明人:
KUNSTELJ MENCI,MENART VIKTOR,AMBROZIC GABRIELA,GABERC POREKAR VLADKA
申请号:
IN1624/MUMNP/2010
公开号:
IN259823B
申请日:
2010.07.29
申请国别(地区):
IN
年份:
2014
代理人:
摘要:
The invention relates to a modifying agent comprising a water soluble polymer, wherein the water soluble polymer comprises at least one reactive selenium group, said reactive selenium group being capable of reacting with a thiol group thereby forming an -Se-S- bond. Furthermore, the invention relates to a method for producing said modifying agents and their use in the modification of pharmaceutically active agents, e.g. G-CSF. Additionally, the invention concerns conjugates comprising a water-soluble polymer and a pharmaceutically active agent, wherein the water-soluble polymer is linked via a S-Se-bond to agent and a method for their production and their use as medicaments. Finally, the invention concerns a pharmaceutical composition comprising the inventive conjugates.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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