MYASOEDOV, NIKOLAI FEDOROVICH,ANDREEVA, LYUDMILA ALEXANDROVNA,GOLIKOV, DMITRY VIKTOROVICH,LOMONOSOV, MIKHAIL YURIEVICH
申请号：
CA3041456
公开号：
CA3041456A1
申请日:
2017.10.02
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The invention relates to peptide chemistry, pharmacology, and medicine, and specifically to a new group of peptides having the property of stimulating sexual and genital function and having increased storage stability. For this purpose, peptides of general formula (I) are proposed: A-Thr-Lys-Hyp-?-?-?-?, in which A is 0, Met, Met(0), Thr, Ala, His, Phe, Lys, Gly； ? is 0, Gly, Asp, Trp, Gin, Asn, Tyr, Hyp, Arg； ? is 0, Arg, Phe, Tyr, Gly, His, Hyp, Lys； ? is 0, Val, Gly, Tyr, Trp, Phe, His； X is OH, OCH3, NH2； where 0 is the absence of an amino acid residue, provided that if ? ? 0, then ? and/or ? and/or ? ? 0, if ? ? 0, then ? and/or ? ? 0, wherein tetrapeptides as well as the peptides Phe-Thr-Lys-Hyp-Gly, Thr-Lys-Hyp-Hyp-Arg and Thr-Lys-Hyp-Arg-Gly are excluded. The invention also relates to pharmaceutical compositions containing said peptides, as well as to the use of said compositions to treat women with severely decreased libido or completely absent libido, orgasmic dysfunction, sexual dysfunction not caused by organic disorders or diseases, HSDD, FSAD, or FSIAD, and to a method of treating and/or preventing female sexual dysfunction.
