GOVINDAN SERENGULAM V,GALE JONATHAN B,HOLMAN NICHOLAS J,GOLDENBERG DAVID M
申请号：
IN11166/DELNP/2015
公开号：
IN2015DN11166A
申请日:
2015.12.07
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention concerns improved methods and compositions for preparing SN 38 conjugates of proteins or peptides preferably immunoconjugates of antibodies or antigen binding antibody fragments. More preferably the SN 38 is attached to the antibody or antibody fragment using a CL2A linker with 1 12 more preferably 6 or less most preferably 1 5 SN 38 moieties per antibody or antibody fragment. Most preferably the immunoconjugate is prepared in large scale batches with various modifications to the reaction scheme to optimize yield and recovery in large scale. Other embodiments concern optimized dosages and/or schedules of administration of immunoconjugate to maximize efficacy for disease treatment and minimize side effects of administration.
