Govindan, Serengulam V.,Gale, Jonathan B.,Holman, Nicholas J.,Goldenberg, David M.
申请号：
AU2014293670
公开号：
AU2014293670B2
申请日:
2014.04.17
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
The present invention concerns improved methods and compositions for preparing SN-38 conjugates of proteins or peptides, preferably immunoconjugates of antibodies or antigen-binding antibody fragments. More preferably, the SN-38 is attached to the antibody or antibody fragment using a CL2A linker, with 1-12, more preferably 6 or less, most preferably 1-5 SN-38 moieties per antibody or antibody fragment. Most preferably, the immunoconjugate is prepared in large scale batches, with various modifications to the reaction scheme to optimize yield and recovery in large scale. Other embodiments concern optimized dosages and/or schedules of administration of immunoconjugate to maximize efficacy for disease treatment and minimize side effects of administration.
