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SKIN LIGHTENING COMPOSITIONS
专利权人:
ELC Management LLC
发明人:
Niki, Yoko,Yarosh, Daniel B.,Matsui, Mary S.,Yoshida, Masaki,Ichihashi, Masamitsu,Ando, Hideya
申请号:
AU2015200590
公开号:
AU2015200590B2
申请日:
2015.02.06
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
#$%^&*AU2015200590B220160505.pdf#####ABSTRACT Compositions and methods for lightening and/or depigmenting skin are provided, the compositions comprising compounds having the structure: Formula (I), wherein: R1 and R2 are 5 same or different and are each selected from the group consisting of hydrogen, alkyl, carbomethoxy, carboethoxy, alkoxy, and alkanoyl, any of which may be halogen-substituted, and halogen R6 is selected from the group consisting of hydrogen, methyl, and ethyl and R3, R4 and R5 are the same or different and are each selected from the group consisting of hydrogen, methyl, methoxy, ethoxy, methoxyethoxy, ethoxyethoxy, propoxy, 10 propoxymethoxy, and the like, any of which may be halogen-substituted or having the structure: Formula (II), wherein: R2 is hydrogen, lower alkyl or hydroxy lower alkyl R 3 is lower alkyl, -CH 2CN, hydroxy lower alkyl, -NO, -CH 2N=C or (wherein R6 and R 7 are independently selected from the group consisting of hydrogen and lower alkyl) or hydrogen provided R2 is not hydrogen R4 is Z-T-W wherein Z represents -0-, -NH- or a single bond T 15 represents a straight- or branched-chain lower-alkylene group when Z is a single bond, T also represents an ethenylene or a propenylene group wherein the unsaturated carbon is at the single bond when Z is -0-, T also represents an allylene group wherein the saturated carbon is at the oxygen and W represents hydrogen, when T is allylene and Z is -0-, and Ar, wherein Ar is selected from thienyl, pyridinyl, furanyl, phenyl and substituted phenyl wherein there are 20 one or more substituents on the phenyl independently selected from halogen or lower alkyl and R5 is hydrogen, halogen or lower alkyl or pharmaceutically-, cosmetically- and dermatologically-acceptable salts, solvates, and bioprecursors, and stereoisomers and enantiomers of these compounds, free from or mixed with other enantiomers or stereoisomers and such compounds in compositions with a pharmaceutically-, cosmetically- or 25 derm
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