HUMAN ANTIBODIES THAT BIND HUMAN TNF-ALPHA AND METHODS OF PREPARING THE SAME

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专利权人:

ABBVIE INC.

发明人:

CHUMSAE, CHRIS, M.

申请号：

EP13877986

公开号：

EP2830651A4

申请日:

2013.11.12

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

Methylglyoxal (MGO)-modified recombinant TNF-alpha antibodies (e.g., Adalimumab) are identified. MGO modification decreases binding between Adalimumab and TNF-alpha. Methods are disclosed for reducing the presence of MGO-modified antibodies in the production of Adalimumab TNF-alpha antibodies.

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中国工程科技知识中心

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http://www.ckcest.cn/home/