HUMAN ANTIBODIES THAT BIND HUMAN TNF-ALPHA AND METHODS OF PREPARING THE SAME

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专利权人:

ABBVIE INC.

发明人:

CHUMSAE, CHRIS, M.

申请号：

SG11201507230P

公开号：

SG11201507230PA

申请日:

2013.11.12

申请国别(地区):

SG

年份:

2015

代理人:

摘要：

Methylglyoxal (MGO)-modified recombinant TNF-alpha antibodies (e.g., Adalimumab) are identified. MGO modification decreases binding between Adalimumab and TNF-alpha. Methods are disclosed for reducing the presence of MGO-modified antibodies in the production of Adalimumab TNF-alpha antibodies.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/