The vascular new life restrainer which shows the effect of treatment which is higher than former ones and the vascular new life suppression manner which utilizes that are offered.From the group which consists of miRNA, pre miRNA, and pri miRNA which show miRNA activity vis-a-vis the VE cadherin the vascular new life restrainer which at least contains miRNA of 1 where it is chosen genera.従来のものよりも高い治療効果を示す血管新生抑制剤及びそれを利用する血管新生抑制方法を提供する。VE-カドヘリンに対してmiRNA活性を示すmiRNA、pre-miRNA、及びpri-miRNAからなる群より選択される少なくとも1種のmiRNA類を含有する血管新生抑制剤。