Piperazinylpiperidine derivatives as chemokine receptor antagonists

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专利权人:

Chu-Biao Xue

发明人:

Chu-Biao Xue,Ganfeng Cao,Taisheng Huang,Lihua Chen,Ke Zhang,Anlai Wang,David Meloni,Rajan Anand,Joseph Glenn,Brian W. Metcalf

申请号：

US12422517

公开号：

US08268826B2

申请日:

2009.04.13

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention relates to compounds of Formula I:wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.

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