Shi-Ming Yang,Nan Wu,Yan Wu,Dong Han,Wei-Wei Guo,Li-Dong Zhao,Suo-Quiang Zhai,Wei-Quiang Gao,Wei-Yen Young
申请号：
US13978060
公开号：
US20140004196A1
申请日:
2012.01.04
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Polyamidoamine, its partially degraded products or its complexes-Math1 gene nanoparticles, method for preparing the same and use thereof, the gene nanoparticles can be produced through complex coacervating of polyamidoamine, or polyamidoamine complexes and a Math1 gene-containing plasmid. The gene nanoparticles are controllable in particle size, uniform in size, favorable for surface modification, can enhance the ability of expression and delivery of the Math1 gene, and is useful in a sensorineural hearing loss caused by hair cells loss due to noise, drug toxicity etc.
