President and Fellows of Harvard College;The General Hospital Corporation
发明人:
David A. Sinclair,Maria Alexander-Bridges
申请号：
US14460397
公开号：
US09597347B2
申请日:
2014.08.15
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
