method for regulating blood glucose levels, method for increasing insulin secretion or promoting release of insulin into the bloodstream, method for treating a disease or condition, method for delaying the onset of a disease or disease condition kit, compound of pharmaceutical composition
ANDREW ASHER PROTTER,MICHAEL JOHN GREEN,RAJENDRA PARASMAL JAIN,SARVAJIT CHAKRAVARTY
申请号：
BR112013021125
公开号：
BR112013021125A2
申请日:
2012.02.17
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor &alpha；2B antagonists. The compounds may also bind to and antagonize adrenergic receptor &alpha；1B. The compounds may find use in therapy, e.g., to (i) reduce blood pressure and/or (ii) promote renal blood flow and/or (iii) decrease or inhibit sodium reabsorption. The compounds may also be used to treat diseases or conditions that are, or are expected to be, responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular and renal disorders is particularly described.
