The invention relates to a novel free-flowing powder pharmaceutical formulation for the delivery of a poorly-water-soluble drug substance that increases the solubility and bioavailability of the poorly- water soluble drug substance, as well as to a method of making the free-flowing powder pharmaceutical formulation. The invention also relates to dispersed particles that disperse instantaneously from the free-flowing powder formulation when the formulation is added to water, aqueous solvent, or organic solvent, wherein the bulk distribution of the poorly-water soluble drug substance of the free-flowing powder formulation in the dispersed particles is uniform. Such dispersed particles increase the bioavailable surface area of the poorly water-soluble drug substance and facilitate the drug substances dissolution.Linvention concerne une nouvelle formulation pharmaceutique en poudre fluide pour ladministration dune substance pharmaceutique faiblement hydrosoluble qui augmente la solubilité et la biodisponibilité de la substance pharmaceutique faiblement hydrosoluble, ainsi quun procédé de fabrication de la formulation pharmaceutique en poudre fluide. Linvention concerne en outre des particules dispersées qui se dispersent instantanément à partir de la formulation en poudre fluide lorsque la formulation est ajoutée à de leau, un solvant aqueux, ou un solvant organique, la distribution en vrac de la substance pharmaceutique faiblement hydrosoluble de la formulation de poudre fluide dans particules dispersées est uniforme. De telles particules dispersées augmentent la surface biodisponible de la substance pharmaceutique faiblement hydrosoluble et facilitent la dissolution de la substance pharmaceutique.
