CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO)
发明人:
PASTOR FERNÁNDEZ, JOAQUÍN,ÁLVAREZ ESCOBAR, ROSA MARÍA,RIESCO FAGUNDO, ROSARIO CONCEPCIÓN,GARCÍA GARCÍA, ANA BELÉN,RODRÍGUEZ HERGUETA, ANTONIO,MARTÍN HERNANDO, JOSE IGNACIO,BLANCO APARICIO, CARMEN,CEBR
申请号：
SG11201400681U
公开号：
SG11201400681UA
申请日:
2012.05.18
申请国别(地区):
SG
年份:
2014
代理人:
摘要：
There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.
