(I) The present invention relates to spiro (tetracarbon) substituted compoundof Formula I, processes for their preparation, pharmaceutical compositionscontaining them as active ingredient, methods for the treatment of disease statesassociated with angiogenesis, such as cancers associated with protein tyrosinekinases, to their use as medicaments for use in the production of inhibition oftyrosine kinases reducing effects in warm-blooded animals such as humans.