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COMPOSITIONS AND METHODS FOR KINASE-MEDIATED CYTOPROTECTION AND ENHANCED CELLULAR ENGRAFTMENT AND PERSISTENCE
专利权人:
San Diego State University (SDSU) Foundation; dba San Diego State University (SDSU) Research Founda
发明人:
Mark A. SUSSMAN
申请号:
US14304920
公开号:
US20150079049A1
申请日:
2014.06.14
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Disclosed are methods of protecting cells, especially non-vascular system, non-hematopoietic cells and tissues, from apoptosis and enhancing their engraftment, survival, and/or persistence by providing enhanced levels of PIM activity for the cell, including PIM-1 activity. Also disclosed are cells that have been engineered to express enhanced levels of PIM kinase, and methods of administering those cells to vertebrates.
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