A child-resistant lift-off cap for a container is adapted to be difficult to unseat independently to open the container. An overlay portion associated with the cap is adapted for use to lift the cap from a container to unseat it. The overlay portion has a thumb tab and is deformable to engage and lift the seated cap only when the thumb tab is lifted. The overlay portion raises independently of the cap when the deformable portion is not deformed into engagement with the cap. Alternatively, a lift-top cap having a slot through it, the slot having a first opening near an edge of the cap to be lifted to unseat the cap and a second opening. A slide in the slot has a first end biased to be flush with or recessed into the first opening and a second end biased to normally protrude out of the second opening. The second end of the slide can be depressed against the bias of the slide to displace the first end of the slide out of the first opening to function as a thumb tab to assist in lifting the cap from a container.