The present invention relates to a nanoemulsion in gel-form comprising a continuous aqueous phase and at least one dispersed oily phase, in which:the aqueous phase comprises:at least one co-surfactant including at least one polyalkoxylated chain consisting of ethylene oxide or ethylene oxide and propylene oxide units, andat least one hydrophilic agent of interest, andthe oily phase comprises:at least one amphiphilic lipid,at least one solubilizing lipid consisting in a mixture of saturated fatty acid glycerides including: at least 10% by weight of C12 fatty acids,at least 5% by weight of C14 fatty acids,at least 5% by weight of C16 fatty acids, andat least 5% by weight of C18 fatty acids,at least one lipophilic agent of interest,said hydrophilic and lipophilic agents of interest being independently selected from among:a therapeutic agent,an optical agent selected from among a coloring agent, a chromophore, a fluorophore, anda physical agent selected from among a radioactive isotope and a photosensitizer.It also relates to a method for the preparation and the use of this nanoemulsion for delivery of at least two agents of interest.
