Refers to a compound of formula (i), where l is a Group # cr7ar7b - (1 - cr8ar8b) - # m 2, in which # 1 is the point of attachment to the carbonyl Group, # 2 is the point of attachment to the pyrimidine ring, M is 0 - 2, R7a is H, Fluorine alkyl, among others R7b is H, difluorometilo, trifluoromethyl, among other S r8a is H, alkyl, Hydroxy, Fluorine, Fluorine, r8b is H, alkyl,Trifluoromethyl Q is a heteroaryl Ring 8 or 9 members R3 is or4 -, where - nr5r6, R4 is H, alkyl, cycloalkyl, among others R5 R6 is H, alkyl, cycloalkyl alkyl, phenyl, among others r1 is Fluorine, Chlorine, cyano, among others R2 is trifluoromethyl alkyl n is 0 - 2.Preferred compounds are ethoxy - 4 - 2 - [1 - (2-fluorobenzyl) - 1H pyrazolo [3,4-b] pyridin-3-yl) - 5,5 - Dimethyl 5,7 - dihydro - 5h pyrrolo [2,3-d] pyrimidine 6 - One 4 - (Cyclopropylmethoxy) - 2 - [1 - (2-fluorobenzyl) - 1H pyrazolo [3,4-b] pyrimidine 6 - Ona, among others. It also relates to a Pharmaceutical composition that is useful for the treatment of cardiovascular diseases.SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDE L REPRESENTA UN GRUPO #1-CR7AR7B-(CR8AR8B)m- #2, EN LA QUE #1 ES EL PUNTO DE UNION AL GRUPO CARBONILO, #2 ES EL PUNTO DE UNION AL ANILLO PIRIMIDINA, m ES 0-2, R7A ES H, FLUOR, ALQUILO, ENTRE OTROS R7B ES H, DIFLUOROMETILO, TRIFLUOROMETILO, ENTRE OTROS R8A ES H, FLUOR, ALQUILO , HIDROXI R8B ES H, FLUOR, ALQUILO , TRIFLUOROMETILO EL ANILLO Q ES UN HETEROARILO DE 8 O 9 MIEMBROS R3 ES -OR4, -NR5R6, DONDE R4 ES H, ALQUILO, CICLOALQUILO, ENTRE OTROS R5 ES H, ALQUILO R6 ES ALQUILO, CICLOALQUILO, FENILO, ENTRE OTROS R1 ES FLUOR, CLORO, CIANO, ENTRE OTROS R2 ES TRIFLUOROMETILO, ALQUILO, ENTRE OTROS n ES 0-2. SON COMPUESTOS PREFERIDOS 4-ETOXI-2-[1-(2-FLUOROBENCIL)-1H-PIRAZOLO[3,4-B)PIRIDIN-3-IL]-5,5-DIMETIL-5,7-DIHIDRO-6H-PIRROLO[2,3-D]PIRIMIDIN-6-ONA 4-(CICLOPROPILMETOXI)-2-[1-(2-FLUOROBENCIL)-1H-PIRAZOLO[3,4-B]PIRIMIDIN-6-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE ES UTIL PARA EL TRATAM
