JOSHUA C. ANTHONY,KRISTIN L. MORRIS,JUAN M. GONZALEZ,JOHN ALVEY,BRADLEY J. TAYLOR,HUGH N. TUCKER,EDUARD K. POELS
申请号：
MX2012009099
公开号：
MX342445B
申请日:
2011.02.24
申请国别(地区):
MX
年份:
2016
代理人:
摘要：
The present disclosure provides formulations and methods for delivering water-soluble and lipid-soluble nutrients for preventing or correcting nutrient deficiencies to subjects requiring small-volume nutritional support, such as preterm infants. The formulations may comprise an emulsion of docosahexaenoic acid (DHA) stabilized by a protein emulsifier, such as alpha-lactalbumin, and may further comprise other valuable nutrients, such as arachidonic acid (ARA), arginine, glutamine, arginyl-glutamine dipeptide and/or alanyl-glutamine dipeptide. The formulation is useful, for example, for correcting nutritional deficiencies by increasing a subject's intake of nutrients such as omega-3 or omega-6 long-chain polyunsaturated acids, proteins, peptides, vitamins, minerals, other fatty acids, and/or essential amino acids. The nutritional formulation is suitable for enteral delivery and small-volume delivery via nasogastric tube, intragastric feeding, transpyloric administration and/or any other means of administration that result in the introduction of the nutritional formulation into the digestive tract of a subject.La presente invención se refiere a una formulación nutricional, caracterizada porque consiste de: una emulsión que comprende aproximadamente 1 a 5% p/p de ácido docosahexaenoico, en donde la emulsión es dispersada en un componente acuoso que comprende una componente aminoácido que comprende； (i) arginina y dipéptido de alanil-glutamina o (ii) dipéptido de arginil-glutiamina； un emulsificante que comprende 90-100% p/p de ?-lactalbúmina, en donde la formulación nutricional comprende aproximadamente 0.1 a 1.0% p/p de la ?-lactalbúmina, y ácido araquidónico, en donde la ?-lactalbúmina, y ácido araquidónico； en donde la ?-lactalbúmina está presente en una interfaz entre el componente acuoso y el ácido docosahexaenoico para estabilizar la emulsión； y en donde la formulación nutricional es envasada en un envase de dosis única de hasta 2 ml.
