A medical instrument with a hollow shaft and a handle mounted on the proximal end of the shaft, such that the shaft can be rotated around its longitudinal axis by a power drive, and such that the power drive is configured as an adjusting wheel that can both be rotated around the longitudinal axis of the shaft and also moved in the longitudinal direction of the shaft. To provide a medical instrument whose power drive makes simple and secure operation of the shaft rotation possible, the power drive can be actuated in every working position in one-handed operation, independently of any other actuation of the handle.