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Compositions and Methods for Inducing an Enhanced Immune Response Using Poxvirus Vectors
专利权人:
Bavarian Nordic A/S
发明人:
Jürgen Hausmann,Michael Wolferstätter
申请号:
US16846325
公开号:
US20200325477A1
申请日:
2020.04.11
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Provided herein are recombinant poxviruses comprising heterologous or native nucleic acids specifying excess double-stranded RNA (dsRNA) early in infection, which may further comprise heterologous nucleic acids encoding one or more costimulatory molecules, and/or heterologous nucleic acids encoding one or more infectious disease-associated antigens or tumor-associated antigens, as well as pharmaceutical compositions comprising such recombinant poxviruses and methods and uses thereof. The recombinant poxviruses provided herein enhance innate and adaptive immune activation in subjects compared to identical recombinant poxviruses lacking heterologous or native transcription units specifying excess early dsRNA.
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