#$%^&*AU2019268149A120191212.pdf#####ABSTRACT The present invention provides compositions or vaccines that contain a recombinant or an attenuated Leptospira interrogans that elicit an immune response in animals against Leptospira infection, including compositions comprising said recombinant or attenuated L. 5 interrogans, methods of vaccination against Leptospira, and kits for use with such methods and compositions.