Ron L. Hale,Craig C. Hodges,Peter M. Lloyd,Amy T. Lu,Daniel J. Myers,Joshua D. Rabinowitz,Martin J. Wensley,Jeffrey A. McKinney,Alejandro C. Zaffaroni
申请号：
US13569006
公开号：
US20130032139A1
申请日:
2012.08.07
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided, wherein the device, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Methods for use are also disclosed.
