National University Corporation Hokkaido University
发明人:
申请号:
EP17744471.8
公开号:
EP3409772A1
申请日:
2017.01.27
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention pertains to a complex including nanoparticles and, carried on the surface of the nanoparticles, a lysosomal enzyme inhibitor or kinase inhibitor shown by general formula (A) and a phospholipid mimetic substance shown by general formula (B).In general formula (A), n1 is an integer of 2-30, n2 is an integer of 2-30, the -S-terminal is a nanoparticle-carrying site, and R10 is a suicide substrate site or a kinase inhibition site. In general formula (B), n3 is an integer in the range of 2-30, and the -S- terminal is a nanoparticle-carrying site. The present invention provides a versatile system capable of efficiently delivering a drug to endolysosomes and allowing the drug to function at a low concentration on lysosomal enzymes, and an anticancer agent in which this system is used.