PROBLEM TO BE SOLVED: To provide a method for stably creating a periodontitis model precisely and sufficiently reproducing human periodontitis in a short period, and to provide the periodontitis model animal.SOLUTION: The method for creating the periodontitis model includes previously systemically administering a periodontitis causative antigen to a nonhuman animal, and topically administering the periodontitis causative antigen to the surface of the gum of the nonhuman animal.COPYRIGHT: (C)2011,JPO&INPIT【課題】ヒトの歯周炎を確実かつ十分に、しかも短期間で再現する歯周炎モデルを安定に作製する方法及び歯周炎モデル動物を提供する。【解決手段】非ヒト動物にあらかじめ歯周病原因性抗原を全身投与した後に、該非ヒト動物の歯肉表面に前記歯周病原因性抗原を局所投与する歯周炎モデル作製方法。【選択図】なし
