KONG, NORMAN XIANGLONG,孔祥龙,孔祥龍,ZHOU, CHAO,周超,ZHENG, ZHIXIANG,郑之祥,鄭之祥
申请号：
TW108122091
公开号：
TW202019939A
申请日:
2019.06.25
申请国别(地区):
TW
年份:
2020
代理人:
摘要：
The present invention relates to a compound, a pharmaceutical composition containing the compound, and a preparation method therefor, and the use of same as a TRK inhibitor. The compound is a compound as shown in formula I, or a pharmaceutically acceptable salt, prodrug, solvate, polymorph, isomer or stable isotopic derivative thereof. The present invention also relates to use of the compound for treating or preventing TRK-mediated related diseases, such as tumors, and a method for applying the compound to treating the diseases.本發明涉及化合物、含有其的藥物組合物、以及它們的製備方法, 和其作為TRK抑制劑的用途。所述化合物為式I所示的化合物，或其藥學上可接受的鹽、前藥、溶劑化合物、多晶型體、異構體、穩定同位素衍生物。本發明還涉及所述化合物用於治療或預防由TRK介導的相關疾病例如腫瘤的用途以及應用其治療所述疾病的方法。
