An ultrasonic endovascular clearing device for use in a bodily lumen includes a powering handle configured to enclose one or more acoustic drivers, an acoustic amplifier and/or acoustic matching section including one or more amplifiers and/or matching elements and a driven wire. The acoustic drivers are configured to produce acoustic vibration in the ultrasonic frequency range. The amplifier/matching section matches and amplifies the acoustic vibration and drives the wire accordingly. The wire cleans due to one or both of a) its asymmetric shape being driven, b) its feature-enhanced surface being driven, whether on an asymmetric wire or not. The driving is pulsed or continuous, cavitating or noncavitating, and torsional or radial/lateral in its possible operational embodiments. A drug may be used by or delivered by the device and wire/tissue parameter sensing is optionally provided.
