MALKIN, Hugh,HASTINGS, Nicholas James,WILLIAMSON, Finbarr Charles Ronald
申请号：
GBGB2017/053799
公开号：
WO2018/115839A1
申请日:
2017.12.19
申请国别(地区):
GB
年份:
2018
代理人:
摘要：
Apparatus for distributing a solid dosage form in an extraction fluid comprises: (a) a sample preparation bag for containing said solid dosage form and an extraction fluid, the bag comprising flexible walls defining a sample preparation chamber having an opening through which solid dosage forms may be passed, the sample preparation chamber comprising: (i) an opening-proximal upper reservoir zone for receiving one or more solid dosage forms via the opening； (ii) an opening-distal lower reservoir zone for containing pulverized solid dosage form and/or extraction fluid； and (iii) a pulverizing zone between the upper and lower reservoir zones, wherein the pulverizing zone comprises opposed crusher plates fixed to a portion of each of the inner surfaces of two opposed walls of the bag； (b) a jaw crusher for pulverizing said solid dosage form contained within the sample preparation bag, the crusher comprising: (i) an upper pulverizer assembly comprising a pair of opposed jaws, said jaws being moveable relative to one another and each comprising opposed upper and lower crushing surfaces for contacting the outer surfaces of the pulverizing zone of the sample preparation bag and thereby exerting a crushing force on a solid dosage form contained therein via the crusher plates of the bag； and (ii) a lower pump assembly comprising pumping means comprising a member for contacting an outer surface of the lower reservoir zone of the sample preparation bag and thereby displacing extraction fluid contained therein to the pulverizing zone thereof； wherein the opposed upper crushing surfaces are adapted to nip with a first stroke length l and at a first frequency f and the opposed lower crushing surfaces are adapted to nip with a second stroke length l 2 at a second frequency f 2, and wherein l >； l 2 and f <； fL'invention concerne un appareil destiné à distribuer une forme de dosage solide dans un fluide d'extraction et comportant: (a) une poche de préparation d'échantillon serva
