GLUNZ, PETER W.,LADZIATA, VLADIMIR,DE LUCCA, INDAWATI,TORA, GEORGE O.,MAISHAL, TARUN KUMAR,TANGIRALA, RAGHURAM,THIYAGARAJAN, KAMALRAJ
申请号:
CA3069311
公开号:
CA3069311A1
申请日:
2018.07.11
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.