SHI, Shuiping,ZHANG, Qingyong,ZHAO, Ronghua,CHEN, Huihong,ZENG, Lun,OU, Daxin,LIU, Yan
申请号：
EP16877705
公开号：
EP3395346A4
申请日:
2016.12.20
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
An oral preparation for treating cell proliferation diseases. The oral preparation comprises hydroxylpropoxyl-²-cyclodextrin and an active component. The active component is KX2-361 or a medicinal salt thereof, and KX2-361 is represented by formula 1. By mixing hydroxylpropoxyl-ydcyclodextrin with KX2-361 or the medicinal salt thereof, an inclusion complex is formed, the solubility of the poorly-soluble drug KX2-361 is greatly improved, and accordingly the drug is prepared into an oral preparation. The oral preparation has good stability, high safety, good absorbability, high bioavailability and economical cost.
