The present invention relates to the context of renal denervation. In order to provide further improvement in relation to the outcome of renal denervation, an apparatus (10) for renal denervation preparation is provided that comprises an input unit (12), a processing unit (14) and an output unit (16). The input unit is configured to receive first artery parameter data and second artery parameter data. The first artery parameter data relates to artery stiffness of a renal artery part of a subject, and the second artery parameter data relates to artery stiffness of a non-renal artery part of the subject. The processing unit is configured to calculate a respective vessel stiffness for the renal artery part based on the first artery parameter data, and to calculate a respective vessel stiffness for the non-renal artery part based on the second artery parameter data, and also to determine a response parameter for renal denervation based on the vessel stiffness for the renal artery part and the vessel stiffness for the non-renal artery part. The output unit is then configured to provide the response parameter.
