A system and method enabling the receipt of image data of a patient,identification ofone or more locations within the image data depicting symptoms of lungdisease, analyzingairways and vasculature proximate the identified locations, planning a pathwayto the one ormore locations, navigating an extended working channel to one of thelocations, identifyingthe direction of blood flow within vasculature serving the location,positioning a catheterproximate the location, and temporarily isolating a portion of the identifiedvasculatureserving the location depicting symptoms of lung disease.
