The present invention provides topical formulations and methods that include a charged bioactive agent complexed with an amphipol polymer for dermal and transdermal delivery, and optionally further comprising a TJ modulating peptide. [Selection diagram] Figure 1本発明は、皮膚送達及び経皮送達のためにアンフィポールポリマーと複合体化した荷電した生物活性剤を含み、任意でさらにTJ調節ペプチドを含む、局所製剤及び方法を提供する。【選択図】図1