PROTEINE LYOPHILISEE STABLE A LA TEMPERATURE AMBIANTE

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专利权人:

INC.;REGENERON PHARMACEUTICALS

发明人:

TANG, XIAOLIN,LUDWIG, DAVID BRETT

申请号：

CA3039655

公开号：

CA3039655A1

申请日:

2017.10.06

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

Stable lyophilized therapeutic protein compositions and their methods of manufacture are provided. Specifically, the use of water as a solid cake plasticizer and protein stabilizer is described. Also, the inclusion of a multicomponent stabilizer comprising a larger molecular entity and a smaller molecular entity is described. Also, the inclusion of post-drying annealing under certain conditions improves protein stability. Proteins are predicted to remain stable over 24 months at 25°C.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/