Pharmaceutical composition containing (2R)-methyl-1-3-[2-(3-pyridinyloxy)ethoxy]-2-pyrazinylpiperazine L-malate for treatment of serotonin-related diseases
Tom Fleck,Magnus Cernerud,Helena Lundstrom,Claes Lofstrom,Margit Pelcman,Alexander Paptchikhine,Emma Andersson,Alf Nygren
申请号：
US13768641
公开号：
US08835439B2
申请日:
2013.02.15
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system.In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I):wherein HA is a pharmaceutically acceptable acid and R1-R4 are each independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, and di-C1-C6-alkylamino-C2-C6-alkoxy.The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
