ANNEAU VAGINAL COMPRENANT DE LA DHEA OU DU SULFATE DE DHEA ET ÉVENTUELLEMENT UN AGENT MODULATEUR DE LA LIBÉRATION DU PRINCIPE ACTIF, UTILE POUR AUGMENTER LA RÉSERVE OVARIENNE CHEZ LES FEMMES ET POUR ATTÉNUER LES SYMPTÔMES ASSOCIÉS À LA MÉNOPAUSE
FUENTES GARCÍA, FRANS ARIEL,CHEN, SHU-CHEN,BELTRÁN APABLAZA, MARIANELA DEL CARMEN
申请号：
EP11879080
公开号：
EP2799042A4
申请日:
2011.12.29
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Sustained-release vaginal ring for comprising dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S) or pharmaceutically acceptable thereof as active principle, and optionally a release-modulating agent of the active principle, wherein the amount of active principle is between 1% to 32% by weight, relative to the total weight of the formulation, and the modulator is selected from: polyvinylpyrrolidone K-30, lactose, microcrystalline cellulose and sodium lauryl sulfate. The vaginal ring of the present invention can be used to increase ovarian reserve in women, to be used as drug in assisted reproduction programs, and to relieve symptoms associated with menopause, such as symptoms of vulvar and vaginal atrophy and sexual dysfunction in postmenopausal women.
