The present invention discloses neurochemical agents and biochemical agentsfor human or mammalian neuro- and body-metabolic imaging, comprising chemicalsinvolved in neuronal or glial function, neuromodulatory processes in the brainof said human or mammalian, vascular function, or organ specific metabolic processessaid neurochemical and biochemical agents are labeled with stable isotopesselected from a group including carbon-13, nitrogen-15, deuterium, fluorine-19or a combination thereof in predetermined positions, so as to enhance the detectabilityof the agents and their metabolic successors.