Mi La Cho,Chul Woo Yang,Sung Hwan Park,Seon Yeong Lee,Min Jung Park,Joo Yeon Jhun,Sun Woo Lim,Byung Ha Chung,Eun Kyung Kim,Jae Kyung Kim,Hyun-Sik Na,Se-Young Kim,Eun Jung Lee,Hyeon-Beom Seo
申请号：
US15903675
公开号：
US20180256519A1
申请日:
2018.02.23
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a composition for preventing or treating mitochondrial diseases caused by immunosuppressants, and immune diseases, containing metformin and, more specifically, to a composition for treating mitochondrial diseases caused by immunosuppressants, containing metformin a pharmaceutical composition for preventing or treating immune diseases, containing, as active ingredients, metformin and an immunosuppressant, which is a target of rapamycin inhibitor (mTOR inhibitor) and a pharmaceutical composite formulation for preventing or treating immune diseases, containing, as ingredients, metformin and a mammalian target of rapamycin inhibitor, wherein the metformin and mammalian target of rapamycin inhibitor are administered simultaneously or separately, or administered in a predetermined sequence. The composition effectively alleviates mitochondrial dysfunction, occurring as a side effect of conventional immunosuppressants, while having a more improved immunosuppressive therapeutic effect, thereby being usable in prevention and treatment of transplant rejection, autoimmune diseases, inflammatory diseases, and the like, all of which require immunosuppression.
