Prevention of C type hepatitis virus-related disease which prevention of C type hepatitis virus-related the useful medicine, is efficient simply disease and/or in remedy and is obtained with selective possible screening method, and particular method and/or the remedy is offered. Prevention of C type hepatitis virus-related disease of this invention and/or screening method of the remedy has featured that the process which appraises the obstruction activity of interaction of C type hepatitis Will score protein and PA28 concerning the suffering inspection substance, is included. As for the aforementioned method, for example it is possible to do the copying activity of lipid metabolism control factor as index. The suffering inspection substance in the aforementioned method has been allowed to have possessed revelation of the PA28 gene or functional obstruction activity. C type hepatitis, the fatty liver, the acutely hepatitis and the chronic hepatitis, the hepatic cirrhosis, the liver cancer, and the insulin resistant disease etc are included in the aforementioned C type hepatitis virus-related disease. Method of this invention quite is useful as the method of obtaining the medicine which is superior in the especially fatty liver or the preventive of the liver cancer and the like and curative effect efficiently.C型肝炎ウィルス関連疾患の予防及び/又は治療に有用な薬剤を、簡便に効率よく選別可能なスクリーニング方法、及び当該方法で得られるC型肝炎ウィルス関連疾患の予防及び/又は治療薬を提供する。本発明のC型肝炎ウィルス関連疾患の予防及び/又は治療薬のスクリーニング方法は、被検物質について、C型肝炎ウィルスコア蛋白質とPA28γとの相互作用の阻害活性を評価する工程を含むことを特徴としている。前記方法は、例えば脂質代謝制御因子の転写活性を指標として行うことができる。前記方法における被検物質は、PA28γ遺伝子の発現又は機能の阻害活性を有していてもよい。前記C型肝炎ウィルス関連疾患には、C型肝炎、脂肪肝、急性肝炎、慢性肝炎、肝硬変、肝臓癌、及びインスリン抵抗性疾患等が含まれる。本発明の方法は、特に脂肪肝又は肝臓癌等の予防、治療効果に優れた薬剤を効率よく得る方法として極めて有用である。
