Problem to be solved: to provide compositions and methods for treating autoimmune diseases including lupus, uveitis and encephalitis.A PKC Inhibitor which is a pyrrolopyrazole compound represented by the following formula.Diagram【課題】狼瘡、ブドウ膜炎及び脳炎を含む自己免疫性疾患を処置するための組成物及び方法の提供。【解決手段】例えば下式で表されるピロロピラゾール化合物であるPKC阻害剤。【選択図】図2