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ANTIRETROVIRAL COMBINATION
专利权人:
СИПЛА ЛИМИТЕД (IN)
发明人:
ЛУЛЛА Амар (IN),МАЛХОТРА Джина (IN)
申请号:
RU2010131006/15
公开号:
RU2010131006A
申请日:
2008.12.24
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A pharmaceutical composition comprising a solid unit dosage form comprising:! (i) ritonavir or a pharmaceutically acceptable salt and ester thereof; ! (ii) darunavir or a pharmaceutically acceptable salt and ester thereof. ! 2. The pharmaceutical composition according to claim 1, which is a tablet formulation comprising said ritonavir in the first layer of the formulation and said darunavir in the second layer of the formulation. ! 3. The pharmaceutical composition according to any one of the preceding paragraphs, further comprising a water-insoluble polymer and / or a water-soluble polymer. ! 4. The pharmaceutical composition according to claim 3, where the ratio of the mass of ritonavir or darunavir to the mass of the polymer is from 1: 1 to 1: 6. ! 5. The pharmaceutical composition according to claim 3, where the polymer is present in at least a ritonavir-containing layer. ! 6. The pharmaceutical composition according to any one of claims 1, 2, 4 or 5, further comprising at least one pharmaceutically acceptable excipient. ! 7. The pharmaceutical composition according to claim 6, where the auxiliary substance includes a plasticizer. ! 8. The pharmaceutical composition according to any one of claims 1, 2, 4, 5 or 7, where darunavir is present in an amount of from 300 to 800 mg. ! 9. The pharmaceutical composition according to any one of claims 1, 2, 4, 5 or 7, where ritonavir is present in an amount of from 50 to 100 mg. ! 10. The pharmaceutical composition according to any one of claims 1, 2, 4, 5, or 7 for use in the treatment of HIV or AIDS. ! 11. The pharmaceutical composition according to claim 3, where the ritonavir-containing layer is obtained by hot melt extrusion of said ritonavir with a polymer. ! 12. A method for treating HIV or AIDS, including1. Фармацевтическая композиция, включающая твердую стандартную лекарственную форму, включающую: ! (i) ритонавир или его фармацевтически приемлемую соль и сложный эфир; ! (ii) дарунавир или его фармацевтически
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