Novel cytotoxic agents that preferentially target leukemia inhibitory factor (LIF) for the treatment of malignancies and as new contraceptive agents

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专利权人:

Inc.;Evestra

发明人:

Nair, Hareesh,Santhamma, Bindu,Nickisch, Klaus

申请号：

AU2016235298

公开号：

AU2016235298A1

申请日:

2016.03.22

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

Described herein are new anti-cancer compounds and methods of using such compounds, acting through a new mechanism of action by simultaneous inhibition of leukemia inhibitory factor (LIF) and MDM2. In one embodiment, a cytotoxic compound has the structure (I) or (II). In an embodiment, a method of treating cancer in a subject comprising administering to a subject a medicament comprising an effective amount of a cytotoxic small molecule compound that inhibits leukemia inhibitory factor or leukemia inhibitory factor receptor.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/