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COMPRIMÉ ORAL À DISSOLUTION RAPIDE
专利权人:
MITSUBISHI TANABE PHARMA CORPORATION
发明人:
NARISAWA, SHINJI,SUGIMOTO, MASAAKI,KITAOKA, KENICHI,OOKAWA, AKIKO,MORIMOTO, MASAYUKI
申请号:
EP12777027
公开号:
EP2702995A4
申请日:
2012.04.20
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
Provided is an orally disintegrating tablet comprising a bitter-tasting pharmaceutically active ingredient in the form of bepotastine or a pharmacologically acceptable salt thereof that enables the bitter taste thereof to be masked, has both superior oral cavity disintegration and adequate hardness, and can be produced with ordinary tablet production equipment. The present invention relates to an orally disintegrating tablet containing bepotastine or a pharmacologically acceptable salt thereof, menthol or cyclodextrin, a water-insoluble polymer, and a disintegrating agent; and a method for producing an orally disintegrating tablet, comprising: 1) a step for obtaining granulated granules by mixing and granulating bepotastine or a pharmacologically acceptable salt thereof, a water-insoluble polymer, and optionally a vehicle, 2) a step for obtaining granules for tableting by mixing the granulated granules, menthol, a disintegrating agent, and optionally a lubricant and/or sweetener, and 3) a step for compressing the granules for tableting.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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