A prodrug composition for skin with twin protecting groups bound by disubstituted benzene is disclosed. The prodrug composition is a derivative of 1,4-bis(tetrahydro-2H-pyran-2-yloxy)benzene. Thereby, the twin protecting groups endow the prodrug composition with improved duration of action and efficiency to a targeted object such as melanocytes or tyrosinase, so as to facilitate distributing the prodrug composition over the stratum basale, in turn promoting melanocytes absorption and tyrosinases transportation as well as metabolism.
