Disclosed is the use of compounds of formula (I) in the manufacture of a prodrug. Also disclosed is a pharmaceutical composition comprising a compound of formula (I). Examples of compound of formula (I) are: 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid methyl ester； 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid methyl ester； 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid methyl ester； 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester and 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester.
